In situ structure and organization of the influenza C virus surface glycoprotein

In situ structure and organization of the influenza C virus surface glycoprotein

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Influenza C virus contains a single surface vista 5 vl5 glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities.Here, the authors apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus sara stedy stand aid budding and membrane fusion.